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THE HAGUE , Feb. 27 (Xinhua) -- Frank de Boer will remain as Ajax coach for another season, the 44-year-old former Dutch international confirmed the decision on Friday in Amsterdam.


De Boer has a contract until 2017 at Ajax, but always told he was ready for a new challenge if an interesting offer from a club in the top European leagues would arrive. On the other hand he always said to be happy at Ajax and didn't mind to stay longer in Amsterdam.


""Now it is time to provide clarity,"" De Boer explained. ""If another club now rings the bell at Ajax or my agent, I will not open the door. I hope this clarity also gives a certain rest.""


""I still feel a certain chemistry with the players,"" De Boer added. ""The boys are eager and want to be the best.""


De Boer started as Ajax coach in December 2010 and captured four consecutive league titles and one Dutch Super Cup. This season he will probably miss the championship with league leaders PSV having a 14-point lead.


On Thursday [url=http://www.airmax90scontateitalia.it/nike-air-max-90-hyperfuse/nike-air-max... Air Max 90 Hyperfuse Uomo Scontate , Ajax qualified for the last 16 of the Europa League by beating Legia Warsaw 3-0 in Poland after a 1-0 win at home. Dnipro Dnipropetrovsk from Ukraine are their next opponents.

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SAN FRANCISCO, July 13 (Xinhua) -- Researchers at the University of California, San Francisco, have shown that cellular antennae called cilia, found on fat-forming cells interspersed in muscle, play a key role in the muscle-to-fat transformation.


The findings Nike Air Max 90 Hyperfuse Scontate , revealed in experiments with mice and published Thursday in Cell, could open up new prospects for regenerative medicine, and one day enable researchers to improve muscle renewal during aging and disease.


Like it or not, as we age, our muscle cells are slowly exchanged, one by one Nike Air Max 90 Ultra Moire Scontate , for fat cells. The process quickens when we injure a muscle, and an extreme form of this process is seen in muscle-wasting diseases such as Duchenne muscular dystrophy (DMD). High levels of intramuscular fat have long been associated with a loss of strength and impaired mobility, as well as more falls in elderly or obese individuals, and in patients with DMD.


"The frailty of age is a huge biomedical problem," said Jeremy Reiter, a professor of biochemistry and biophysics at UCSF and senior author of the new paper. "This study helps pave the way to learn how muscles normally age N... Air Max 90 Ultra Essential Scontate , and provides a new way to possibly improve muscle repair."


Primary cilia are tiny cellular appendages a bit like the cellular tentacles that paramecia and other single-celled critters use to move and gather food. But unlike those motile cilia, primary cilia do not move at all. They stand stiff and solitary on the surface of nearly all of our cells, including neurons, skin cells, bone cells and certain stem cells.


Recent work at Reiter's lab has revealed that primary cilia act much like cellular antennae, receiving molecular cues from neighboring cells Nike Air Max 90 Ultra BR Scontate , and processing environmental signals such as light, temperature, salt balance and even gravity. And previous work has shown that when muscle is injured, fat-forming cells that live alongside muscle cells, called fibroadipogenic progenitors (FAPs), divide and differentiate into fat cells.


Daniel Kopinke Nike Air Max 90 Fiori Scontate , a postdoctoral fellow in the Reiter lab and first author of the new study, found that, unlike muscle cells, the fat-forming FAPs are more likely to carry primary cilia, and that muscle injury further increased the abundance of FAPs with cilia. These observations suggested that cilia might be playing an important role in fat formation.


To test this hypothesis, the research team used two mouse models of muscle injury Nike Air Max 90 Leather Scontate , namely an acute injury model created by injecting damaging agents into mouse muscles and a chronic injury model with progressive loss of muscle fibers such as that seen in in DMD. When the researchers genetically blocked the ability of FAPs to form cilia, both injury models showed lower amounts of fat in muscle. In addition, the loss of cilia not only led to the loss of fat, but also aided muscle regeneration.


Through a series of experiments, the group discovered that genetically engineering cells without cilia had resulted in a low-level activation of the Hedgehog pathway, which was enough to block fatty degeneration of skeletal muscle. When the researchers used other methods to amplify Hedgehog signaling Nike Air Max 90 Essential Scontate , mouse muscle again became less fatty.


With further investigation, the researchers found that a key protein in the Hedgehog pathway called TIMP3 was responsible for the effect. By using a small molecule called batimastat, which mimics the effects of TIMP3, they were able to block injury-induced fat formation in muscle.


"Now for the first time we have a handle on the cell type that turns muscle into fat, and we have a handle on the signaling pathway that controls the conversion," Kopinke was quoted as saying in a news release from UCSF. "Maybe one day we could use this knowledge to improve muscle function."










Chen Yu-chieh of Taichung Bank Chinese Taipei (C) spikes the ball against Karina Krause (L) and Witita Balee of Bangkok Glass Thailand during their classification match in the 2016 Asian Women's Club Volleyball Championship in Laguna Province， the Philippines， Sept. 6， 2016. Bangkok Glass Thailand won 3-0. (XinhuaRouelle Umali)


RIO DE JANEIRO Nike Air Max 90 Bianche Scontate , May 24 (Xinhua) -- Reigning Brazilian Serie A champions Palmeiras claimed top spot in Group E of the Copa Libertadores on Wednesday with a 3-1 victory over Argentina's Atletico Tucuman.


Colombia international defender Yerry Mina opened the scoring at Allianz Parque with a 15th-minute strike before Luis Rodriguez headed in an equalizer just after halftime.


Willian then slotted in Palmeiras' second goal before Ze Roberto struck in second-half injury time as the Sao Paulo outfit secured their fourth win in six matc. Cheap Jerseys China Cheap Jerseys China Cheap Jerseys From China Cheap Jerseys China Free Shipping Cheap MLB Jerseys Cheap NHL Jerseys Cheap Sports Jerseys Cheap Jerseys Sale Wholesale Hats China Wholesale Hoddies China